Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs.
Ontology highlight
ABSTRACT: Abbreviations
CDR: complementarity determining region; FACS: fluorescence-activated cell sorting; ka: association rate; kd: dissociation rate; KD: dissociation constant; scFv: single-chain variable fragment; SPR: surface plasmon resonance.
SUBMITTER: Teixeira AAR
PROVIDER: S-EPMC9467613 | biostudies-literature | 2022 Jan-Dec
REPOSITORIES: biostudies-literature
Publications
Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs.
Teixeira Andre A R AAR D'Angelo Sara S Erasmus M Frank MF Leal-Lopes Camila C Ferrara Fortunato F Spector Laura P LP Naranjo Leslie L Molina Esteban E Max Tamara T DeAguero Ashley A Perea Katherine K Stewart Shaun S Buonpane Rebecca A RA Nastri Horacio G HG Bradbury Andrew R M ARM
mAbs 20220101 1
<h4>Abbreviations</h4>CDR: complementarity determining region; FACS: fluorescence-activated cell sorting; k<sub>a</sub>: association rate; k<sub>d</sub>: dissociation rate; K<sub>D</sub>: dissociation constant; scFv: single-chain variable fragment; SPR: surface plasmon resonance. ...[more]
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