Indirect Method for Estimation of Reference Intervals of Inflammatory Markers.

ABSTRACT:

Background

The direct method for reference interval (RI) estimating is limited due to the requirement of resources, difficulties in defining a non-diseased population, or ethical problems in obtaining samples. We estimated the RI for inflammatory biomarkers using an indirect method (RII).

Methods

C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and presepsin (PSEP) data of patients visiting a single hospital were retrieved from April 2009 to April 2021. Right-skewed data were transformed using the Box-Cox transformation method. A mixed population of non-diseased and diseased distributions was assumed, followed by latent profile analysis for the two classes. The intersection point of the distribution curve was estimated as the RI. The influence of measurement si

SUBMITTER: Kang T 

PROVIDER: S-EPMC9467833 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature