Changes of T lymphocyte subpopulations and their roles in predicting the risk of Parkinson's disease.

ABSTRACT: T lymphocytes are involved in the pathogenesis of Parkinson's disease (PD), while the heterogeneity of T-cell subpopulations remains elusive. In this study, we analyzed up to 22 subpopulations of T lymphocytes in 115 PD patients and 60 matched healthy controls (HC) using flow cytometry. We found that PD patients exhibited decreased naïve CD8⁺ T cells (CD3⁺ CD8⁺ CD45RA⁺ CD45RO^-) and increased late-differentiated CD4⁺ T cells (CD3⁺ CD4⁺ CD28^- CD27^-), compared to HC, which were not affected by anti-parkinsonism medication administration. The proportion of naïve CD8⁺ T cells in PD patients was positively correlated with their severity of autonomic dysfunction and psychiatric

SUBMITTER: He Y 

PROVIDER: S-EPMC9467943 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature