Microbial sophorolipids inhibit colorectal tumour cell growth in vitro and restore haematocrit in Apc^min+/- mice.

ABSTRACT: Sophorolipids are glycolipid biosurfactants consisting of a carbohydrate sophorose head with a fatty acid tail and exist in either an acidic or lactonic form. Sophorolipids are gaining interest as potential cancer chemotherapeutics due to their inhibitory effects on a range of tumour cell lines. Currently, most anti-cancer studies reporting the effects of sophorolipids have focused on lactonic preparations with the effects of acidic sophorolipids yet to be elucidated. We produced a 94% pure acidic sophorolipid preparation which proved to be non-toxic to normal human colonic and lung cells. In contrast, we observed a dose-dependent reduction in viability of colorectal cancer lines treated with the same preparation. Acidic sophorolipids induced apoptosis and necrosis, reduced migration, and

SUBMITTER: Callaghan B 

PROVIDER: S-EPMC9467956 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature