Analysis of genome and methylation changes in Chinese indigenous chickens over time provides insight into species conservation.

ABSTRACT: Conservation of natural resources is a vital and challenging task. Numerous animal genetic resources have been effectively conserved worldwide. However, the effectiveness of conservation programmes and the variation information of species have rarely been evaluated. Here, we performed whole-genome and whole-genome bisulfite sequencing of 90 Chinese indigenous chickens, which belonged to the Tibetan, Wenchang and Bian chicken breeds, and have been conserved under different conservation programmes. We observed that low genetic diversity and high DNA methylation variation occurs during ex situ in vivo conservation, while higher genetic diversity and differentiation occurs during in situ conservation. Further analyses revealed that most DNA methylation signatures are unique within ex situ in v

SUBMITTER: Zeng T 

PROVIDER: S-EPMC9467985 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature