Effect of short-term high fat diet on resistin levels and expression of autophagy-related genes in the cartilage of male rats.

ABSTRACT: Obesity is a significant risk factor for the development of knee osteoarthritis (KOA). However, the precise molecular mechanisms linking obesity to OA remain unclear. In the present study, we investigated the effect of short-term high-fat diet (HFD) on the development of OA and the possible role of the adipokine resistin and autophagy-related genes in mediating this effect. Thirty adult male Wistar rats were equally divided into 2 groups: control and obese groups. Body mass index (BMI), levels of lipid profile, glucose, insulin and HOMA-IR index were significantly higher in the obese group compared with control. Our results revealed significantly higher serum and cartilage resistin levels with a significant increase in the mRNA expressions of toll-like receptor 4 (TLR4), matrix metalloprot

SUBMITTER: Aboudeya HM 

PROVIDER: S-EPMC9468003 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature