Laparoscopic vs. open lower mediastinal lymphadenectomy for Siewert type II/III adenocarcinoma of esophagogastric junction: An exploratory, observational, prospective, IDEAL stage 2b cohort study (CLASS-10 study).

ABSTRACT:

Objective

This study aims to verify the feasibility and efficacy of laparoscopic lower mediastinal lymphadenectomy for Siewert type II/III adenocarcinoma of esophagogastric junction (AEG).

Setting

An exploratory, observational, prospective, cohort study will be carried out under the Idea, Development, Exploration, Assessment and Long-term Follow-up (IDEAL) framework (stage 2b).

Participants

The study will recruit 1,036 patients with cases of locally advanced AEG (Siewert type II/III, clinical stage cT2-4aN0-3M0), and 518 will be assigned to either the laparoscopy group or the open group.

Interventions

Patients will receive lower mediastinal lymphadenectomy along with either total or proximal gastrectomy.

Primary and secondary outcome measures

The primary

SUBMITTER: Li S 

PROVIDER: S-EPMC9468012 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature