Hemodynamic Effects of Sacubitril/Valsartan in Patients with Reduced Left Ventricular Ejection Fraction Over 24 Months: A Retrospective Study.

ABSTRACT:

Background

The effects of sacubitril/valsartan in patients with chronic heart failure with reduced ejection fraction (HFrEF) were recently reported. However, the hemodynamic impact of this well-established treatment in patients with HFrEF has been poorly systematically researched.

Aim

We aimed to investigate the hemodynamic effects of sacubitril/valsartan among patients with HFrEF.

Methods

Between 2016 and 2020, we retrospectively collected data for patients with HFrEF treated at the University Medical Center Mannheim, Germany. Data for 240 patients with HFrEF were available. We systematically analyzed echocardiographic parameters, all-cause hospitalization, and congestion rate.

Results

The left ventricular ejection fraction (LVEF) improved from a median (minim

SUBMITTER: Abumayyaleh M 

PROVIDER: S-EPMC9468101 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature