Fecal sphingolipids predict parenteral nutrition-associated cholestasis in the neonatal intensive care unit.

ABSTRACT:

Background

Parenteral nutrition-associated cholestasis (PNAC) in the neonatal intensive care unit (NICU) causes significant morbidity and associated healthcare costs. Laboratory detection of PNAC currently relies on elevated serum conjugated bilirubin levels in the aftermath of impaired bile flow. Here, we sought to identify fecal biomarkers, which when integrated with clinical data, would better predict risk for developing PNAC.

Methods

Using untargeted metabolomics in 200 serial stool samples from 60 infants, we applied statistical and machine learning approaches to identify clinical features and metabolic biomarkers with the greatest associative potential for risk of developing PNAC. Stools were collected prospectively from infants receiving PN with soybean oil-based lipi

SUBMITTER: Moutinho TJ 

PROVIDER: S-EPMC9468188 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature