Immune modulation as a consequence of SARS-CoV-2 infection.

ABSTRACT: Erroneous immune responses in COVID-19 could have detrimental effects, which makes investigation of immune network underlying COVID-19 pathogenesis a requisite. This study aimed to investigate COVID-19 related alterations within the frame of innate and adaptive immunity. Thirty-four patients clinically diagnosed with mild, moderate and severe COVID-19 disease were enrolled in this study. Decreased ILC1 and increased ILC2 subsets were detected in mild and moderate patients compared to healthy controls. NK cell subsets and cytotoxic capacity of NK cells were decreased in severe patients. Moreover, CD3⁺ T cells were reduced in severe patients and a negative correlation was found between CD3⁺ T cells and D-dimer levels. Likewise, moderate and severe patients showed dimini

SUBMITTER: Gelmez MY 

PROVIDER: S-EPMC9468265 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature