Impact of HIV on Anal Squamous Cell Carcinoma Rates in the United States, 2001-2015.

ABSTRACT:

Background

Incidence of anal squamous cell carcinoma (SCC) has increased in the United States. People living with HIV (PLWH) have an elevated risk of anal SCC, and changes in the number of anal SCCs among PLWH may have influenced general population trends.

Methods

Data were obtained from a linkage of HIV and cancer registries in 12 US regions. The proportion of anal SCCs occurring among PLWH was estimated by sex, age group, and race and ethnicity. To assess the impact of anal SCCs among PLWH on general population trends, annual percent changes (APCs) in incidence rates including and excluding anal SCCs among PLWH were estimated.

Results

Between 2001 and 2015, 14.5% of 16 110 anal SCC diagnoses occurred in PLWH. In 2013-2015, 35% of anal SCCs among men occurred in PLWH

SUBMITTER: Zhang ER 

PROVIDER: S-EPMC9468281 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature