Performance of Cervical Screening a Decade Following HPV Vaccination: The Costa Rica Vaccine Trial.

ABSTRACT:

Background

We investigated the impact of human papillomavirus (HPV) vaccination on the performance of cytology-based and HPV-based screening for detection of cervical precancer among women vaccinated as young adults and reaching screening age.

Methods

A total of 4632 women aged 25-36 years from the Costa Rica HPV Vaccine Trial were included (2418 HPV-vaccinated as young adults and 2214 unvaccinated). We assessed the performance of cytology- and HPV-based cervical screening modalities in vaccinated and unvaccinated women to detect high-grade cervical precancers diagnosed over 4 years and the absolute risk of cumulative cervical precancers by screening results at entry.

Results

We detected 95 cervical intraepithelial neoplasia grade 3 or worse (52 in unvaccinated and 43

SUBMITTER: Hu SY 

PROVIDER: S-EPMC9468298 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature