Prediction of response to systemic treatment by kinetics of circulating tumor DNA in metastatic pancreatic cancer.

ABSTRACT:

Introduction

Pretherapeutic detectable circulating tumor DNA (ctDNA) represents a promising prognostic biomarker for predicting relapse and overall survival in patients with metastatic pancreatic cancer. However, the prognostic value of ctDNA dynamics during treatment has not been studied thus far. We aimed to investigate the correlation between the change of ctDNA levels and response to treatment in patients treated by systemic therapy.

Material and methods

CtDNA detection using liquid biopsy (droplet digital PCR (ddPCR) utilizing KRAS G12/13 and, if negative, Q61 commercial test kits) was prospectively performed on patients with stage IV pancreatic cancer i) prior to initiation of systemic chemotherapy and ii) serially every 2 weeks until restaging. Detection rates,

SUBMITTER: Kirchweger P 

PROVIDER: S-EPMC9468369 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature