Risk factors associated with severe disease in respiratory syncytial virus infected children under 5 years of age.

ABSTRACT:

Objective

To evaluate risk factors for severe disease in children under 59 months of age hospitalized with respiratory syncytial virus (RSV) infection.

Study design

We prospectively enrolled 1,096 cases of laboratory confirmed RSV infection during three consecutive RSV seasons in 2015-2018. Potential risk factors for severe disease were retrieved through patient questionnaires and linkage to national health registries. Need for respiratory support (invasive ventilation, bi-level positive airway pressure, or continuous positive airway pressure), and length of stay exceeding 72 h were used as measures of disease severity. Associations were investigated using multivariable logistic regression analyses. Multiple imputation was used to avoid bias and inference induced by missing

SUBMITTER: Havdal LB 

PROVIDER: S-EPMC9468371 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature