The cuproptosis-related signature associated with the tumor environment and prognosis of patients with glioma.

ABSTRACT:

Background

Copper ions are essential for cellular physiology. Cuproptosis is a novel method of copper-dependent cell death, and the cuproptosis-based signature for glioma remains less studied.

Methods

Several glioma datasets with clinicopathological information were collected from TCGA, GEO and CGGA. Robust Multichip Average (RMA) algorithm was used for background correction and normalization, cuproptosis-related genes (CRGs) were then collected. The TCGA-glioma cohort was clustered using ConsensusClusterPlus. Univariate Cox regression analysis and the Random Survival Forest model were performed on the differentially expressed genes to identify prognostic genes. The cuproptosis-signature was constructed by calculating CuproptosisScore using Multivariate Cox regression analys

SUBMITTER: Wang W 

PROVIDER: S-EPMC9468372 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature