Immune-related gene signature predicts clinical outcomes and immunotherapy response in acute myeloid leukemia.

ABSTRACT:

Background

The immune response in the bone marrow microenvironment has implications for progression and prognosis in acute myeloid leukemia (AML). However, few immune-related biomarkers for AML prognosis and immunotherapy response have been identified. We aimed to establish a predictive gene signature and to explore the determinants of prognosis in AML.

Methods

Immune-related genes with clinical significance were screened by a weighted gene co-expression network analysis. Seven immune-related genes were used to establish a gene signature by a multivariate Cox regression analysis. Based on the signature, low- and high-risk groups were compared with respect to the immune microenvironment, immune checkpoints, pathway activities, and mutation frequencies. The tumor immune dysfun

SUBMITTER: Xu Q 

PROVIDER: S-EPMC9468431 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature