Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress.

ABSTRACT:

Background

Oxidative stress and the resultant hyperpermeability play a vital role in the pathogenesis of diabetic retinopathy (DR). Poldip2 has been implicated in H₂O₂ production, but the effects of capsaicin on poldip2 have not been reported.

Methods

Diabetic Sprague-Dawley (SD) rats induced with STZ were treated with capsaicin or AAV₉-poldip2-shRNA, and human retinal microvascular endothelial cells (HRMECs) were treated with capsaicin or poldip2 siRNA.

Results

Current data indicated that the expression of PPARγ, poldip2, Nox4, VCAM-1, HIF-1α, and VEGF increased in rat retinas with DR and in HRMECs treated with high glucose. The production of ROS or H₂O₂ in the tissues, serum, and cells increased, and the paracel

SUBMITTER: Liu K 

PROVIDER: S-EPMC9468458 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature