Exposure to perfluoroalkyl substances and risk of hepatocellular carcinoma in a multiethnic cohort.

ABSTRACT:

Background & aims

Exposure to poly- and perfluoroalkyl substances (PFAS), a class of persistent organic pollutants, is ubiquitous. Animal studies suggest that PFAS may increase risk of fatty liver and hepatocellular carcinoma (HCC) via impacts on hepatic lipid, amino acid, and glucose metabolism, but human data is lacking. We examined associations between PFAS exposure, altered metabolic pathways, and risk of non-viral HCC.

Methods

In this nested case-control study, pre-diagnostic plasma PFAS and metabolomics were measured in 50 incident HCC cases and 50 individually matched controls from the Multiethnic Cohort (MEC) study. Cases/controls were matched by age, sex, race, and study area. PFAS exposure and risk of HCC were examined using conditional logistic regression. A metab

SUBMITTER: Goodrich JA 

PROVIDER: S-EPMC9468464 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature