Structural magnetic resonance imaging findings and histopathological correlations in motor neuron diseases-A systematic review and meta-analysis.

ABSTRACT:

Objectives

The lack of systematic evidence on neuroimaging findings in motor neuron diseases (MND) hampers the diagnostic utility of magnetic resonance imaging (MRI). Thus, we aimed at performing a systematic review and meta-analysis of MRI features in MND including their histopathological correlation.

Methods

In a comprehensive literature search, out of 5941 unique publications, 223 records assessing brain and spinal cord MRI findings in MND were eligible for a qualitative synthesis. 21 records were included in a random effect model meta-analysis.

Results

Our meta-analysis shows that both T2-hyperintensities along the corticospinal tracts (CST) and motor cortex T2^*-hypointensitites, also called "motor band sign", are more prevalent in ALS patients compared

SUBMITTER: Zejlon C 

PROVIDER: S-EPMC9468579 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature