Amygdala response predicts clinical symptom reduction in patients with borderline personality disorder: A pilot fMRI study.

ABSTRACT: Borderline personality disorder (BPD) is a prevalent, devastating, and heterogeneous psychiatric disorder. Treatment success is highly variable within this patient group. A cognitive neuroscientific approach to BPD might contribute to precision psychiatry by identifying neurocognitive factors that predict who will benefit from a specific treatment. Here, we build on observations that BPD is accompanied by the enhanced impact of the aversive effect on behavior and abnormal neural signaling in the amygdala. We assessed whether BPD is accompanied by abnormal aversive regulation of instrumental behavior and associated neural signaling, in a manner that is predictive of symptom reduction after therapy. We tested a clinical sample of 15 female patients with BPD, awaiting dialectical behavior the

SUBMITTER: Geurts DEM 

PROVIDER: S-EPMC9468714 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature