Silica nanochannels boosting Ru(bpy)₃ ²⁺-mediated electrochemical sensor for the detection of guanine in beer and pharmaceutical samples.

ABSTRACT: Vertically ordered mesoporous silica film (VMSF) with uniform mesoporous channels perpendicular to electrode substrate has a wide range of applications in direct electroanalysis of complex samples. However, the detection of nucleic acid bases is difficult to realize at the commonly used VMSF-modified indium tin oxide (VMSF/ITO) electrode due to the high overpotentials of underlying ITO for many small organic molecules. In this work, we demonstrated an electrochemical method for the sensitive detection of guanine (G) by integration of VMSF/ITO and tris(2,2'-bipyridine) ruthenium (II) [Ru(bpy)₃ ²⁺] redox mediator. Ru(bpy)₃ ²⁺ electrostatically accumulated by VMSF is able to act as an electron shuttle between G and underlying ITO surface, showing el

SUBMITTER: Yang L 

PROVIDER: S-EPMC9468770 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature