Association of Cerebral Blood Flow With Longitudinal Changes in Cerebral Microstructural Integrity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

ABSTRACT:

Importance

Decreased cerebral tissue integrity and cerebral blood flow (CBF) are features of neurodegenerative diseases. Brain tissue maintenance is an energy-demanding process, making it particularly sensitive to hypoperfusion. However, little is known about the association between blood flow and brain microstructural integrity, including in normative aging.

Objective

To assess associations between CBF and changes in cerebral tissue integrity in white matter and gray matter brain regions.

Design, setting, and participants

In this longitudinal cohort study, magnetic resonance imaging was performed on 732 healthy adults from the Coronary Artery Risk Development in Young Adults (CARDIA) study, a prospective longitudinal study (baseline age of 18-30 years) that examined

SUBMITTER: Bouhrara M 

PROVIDER: S-EPMC9468885 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature