The correlation between probiotic use and outcomes of cancer patients treated with immune checkpoint inhibitors.

ABSTRACT: Objective: Immune checkpoint inhibitors (ICIs) have recently demonstrated promising results in improving the prognosis of cancer patients. The goal of this meta-analysis was to determine the impact of probiotic use on the survival of cancer patients treated with ICIs. Methods: Before 3 March 2022, the eligible literature was searched using PubMed, EMBASE, Cochrane Library, Google Scholar, and Clinical trials.gov databases. Overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR) were the primary endpoints. Results: A total of 6 studies met the inclusion criteria, and 1,123 patients were included. Meta-analysis showed a trend for probiotic use to prolong PFS (HR: 0.585, 95% CI: 0.328-1.045, p = 0.070) a

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9468893 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature