Cyclin-dependent kinase 5 contributes to apoptosis of vascular endothelial cells during aortic dissection.

ABSTRACT:

Background

Tearing of inner layer of aorta causes aortic dissection (AD), a severe disease with high morbidity and mortality. The pathological development of AD partially results from apoptotic death of aortic endothelial cells (AECs), the trigger and the molecular regulation of which remain largely unknown. Cyclin-dependent kinase 5 (CDK5) was initially detected in the brain as a proline-directed serine/threonine protein kinase regulating neuronal cell cycle re-entry and arrest. The abnormal expression of CDK5 leads to apoptotic cell death following abortive cell cycle re-entry in some neuronal diseases. Although physiological and pathological roles of CDK5 have been widely investigated, the expression and function of CDK5 in AD have not been reported. Therefore, the aim of the pr

SUBMITTER: Huang J 

PROVIDER: S-EPMC9469115 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature