Analysis of m6A-related signatures associated with the tumor immune microenvironment and predict survival in acute myeloid leukemia.

ABSTRACT:

Background

Most previous studies have focused on the intrinsic carcinogenic pathways of tumors; however, little is known about the potential role of N6-methyladenosine (m6A) methylation in the tumor immune microenvironment (TIME). To better diagnose and treat acute myeloid leukemia (AML), we sought to examine the correlation between m6A regulatory factors and immune infiltration in cases of AML. At the same time, a prognostic model was constructed to predict the survival of AML.

Methods

We extracted data from The Cancer Genome Atlas (TCGA) database, including ribonucleic acid sequencing (RNA-seq) transcriptome data and data on the corresponding clinical characteristics of AML patients. We identified two m6A modification patterns with distinct clinical outcomes and found a si

SUBMITTER: Yuan S 

PROVIDER: S-EPMC9469131 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature