CircRNA_0050486 promotes cell apoptosis and inflammation by targeting miR-1270 in atherosclerosis.

ABSTRACT:

Background

Atherosclerosis (AS) is a chronic inflammatory disease that plays a major role in cardiovascular disease. Circular RNAs (circRNAs) are related to the pathogenesis of AS, including the inflammatory response. This study aimed to explore the underlying mechanisms of circRNAs and how they regulate the inflammatory response in AS.

Methods

Analyzed the expression profile of circRNAs in three oxidized low-density lipoprotein (oxLDL) treated macrophage samples and three macrophage control samples using bioinformatics methods. Expression and biological function of circRNA were verified in oxLDL-induced THP-1 macrophages. MiRNAs and target genes of circRNA were predicted by functional enrichment analysis. Expression and function of circRNA target miRNAs were explored in oxL

SUBMITTER: Wang K 

PROVIDER: S-EPMC9469134 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature