MALT1 serves as a biomarker for estimating disease risk of lupus nephritis: a prospective case-control study.

ABSTRACT:

Background

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) regulates immune/inflammation response and kidney injury, indicating that it might participate in the lupus nephritis (LN) pathology. The present study sought to investigate the utility of MALT1 serving as an indicator of severity and inflammation biomarker in LN.

Methods

In total, 30 LN patients and 30 non-LN systemic lupus erythematosus (SLE) patients were recruited, and blood MALT1 expression was detected using reverse transcription-quantitative polymerase. Besides, the SLE disease activity index was calculated for all subjects to assess disease activity.

Results

MALT1 was more increased in LN patients than non-LN SLE patients {2.26 [interquartile range (IQR): 1.38-3.54] vs.

SUBMITTER: Wang M 

PROVIDER: S-EPMC9469135 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature