The role of ferritin and iron dextran in exacerbating preeclampsia in an L-NAME-treated rat model.

ABSTRACT:

Background

Preeclampsia (PE) occurs in the second half of pregnancy and contributes to maternal and perinatal morbidity and mortality. Ferritin plays a key role in pregnancy, but the underlying mechanisms of its involvement in PE remain elusive. This study aimed to investigate the effects of ferritin concentrations and ferroptosis levels on PE rats at different stages of pregnancy.

Methods

A PE rat model was established by administering nitro-L-arginine methyl ester (L-NAME; 60 mg/kg/day, orally) between the 13th and 19th days of pregnancy. Iron dextran (ID) was used to induce ferroptosis, whereas deferoxamine (DFO) was used to prevent ferroptosis. Pathological changes in the placenta and vascular system were observed by hematoxylin and eosin (H&E) staining. Oxidative stress

SUBMITTER: Zhu X 

PROVIDER: S-EPMC9469136 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature