Landscape of RB1 alterations in 22,432 Chinese solid tumor patients.

ABSTRACT:

Background

The human retinoblastoma susceptibility gene (RB1) is a tumor-suppressor gene mutated at different frequencies in many different cancers. The aim of the present study was to investigate the distribution of overall RB1 mutation and different mutation types in a range of Chinese patients with solid tumors.

Methods

We investigated RB1 mutations in formalin-fixed, paraffin-embedded (FFPE) tissues of cancer patients who underwent next-generation sequencing (NGS) at 3DMed Clinical Laboratory Inc from January 1, 2017 to April 15, 2020.

Results

Genomic alterations in RB1 were identified in 1,712 (7.6%) of 22,432 patients with more than 20 different cancer entities (58% males and 42% females, median age: 60 years). RB1 mutations oc

SUBMITTER: Xu G 

PROVIDER: S-EPMC9469137 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature