The effects of treatment using polydeoxyribonucleotide through extracorporeal shock wave therapy: synergic regeneration effects on atrophied calf muscles in immobilized rabbits.

ABSTRACT:

Background

This study aimed to examine the synergic effects of polydeoxyribonucleotide (PDRN) through extracorporeal shock wave therapy (ESWT) on atrophied calf muscles in cast-immobilized rabbit models.

Methods

Twenty male New Zealand rabbits (aged 12 weeks) were allocated into four groups. Four types of procedures [0.7 mL normal saline to Group 1 (G1-NS); 0.7 mL PDRN to Group 2 (G2-PDRN); ESWT to Group 3 (G3-ESWT); and 0.7 mL PDRN with ESWT to Group 4 (G4-PDRN + ESWT)] were injected to the atrophied calf muscles of the rabbits after two weeks of cast immobilization. Radial ESWT (0.1 mJ/mm², 3 Hz, 1,500 shocks) was performed twice weekly. The circumference of the calves, compound muscle action potential (CMAP) of the tibial nerves, and thickness of the gastrocnem

SUBMITTER: Kim KL 

PROVIDER: S-EPMC9469153 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature