Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy.

ABSTRACT: Whereas treatment of allergic diseases such as asthma relies largely on the targeting of dysregulated effector pathways, the conceptually attractive alternative of preventing them by a pharmaceutical, at-source intervention has been stymied until now by uncertainties about suitable targets and the challenges facing drug design. House dust mites (HDMs) are globally significant triggers of allergy. Group 1 HDM allergens, exemplified by Der p 1, are cysteine proteases. Their degradome has a strong disease linkage that underlies their status as risk and initiator allergens acting directly and through bystander effects on other allergens. Our objective was to test whether target-selective inhibitors of group 1 HDM allergens might provide a viable route to novel therapies. Using structure-direct

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9469500 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature