A blood-based miRNA signature for early non-invasive diagnosis of preeclampsia.

ABSTRACT:

Background

Preeclampsia (PE) is a multisystemic maternal syndrome with substantial maternal and fetal morbidity and mortality. Currently, there is no clinically viable non-invasive biomarker assay for early detection, thus limiting the effective prevention and therapeutic strategies for PE.

Methods

We conducted a discovery-training-validation three-phase retrospective and prospective study with cross-platform and multicenter cohorts. The initial biomarkers were discovered and verified in tissue specimens by small RNA sequencing and qRT-PCR. A miRNA signature (miR2PE-score) was developed using Firth's bias-reduced logistic regression analysis and subsequently validated in two independent multinational retrospective cohorts and two prospective plasma cohorts.

Results

We

SUBMITTER: Bao S 

PROVIDER: S-EPMC9469544 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature