Landscape of the gut archaeome in association with geography, ethnicity, urbanization, and diet in the Chinese population.

ABSTRACT:

Background and aims

The human gut is home to a largely underexplored microbiome component, the archaeome. Little is known of the impact of geography, urbanization, ethnicity, and diet on the gut archaeome in association with host health. We aim to delineate the variation of the human gut archaeome in healthy individuals and its association with environmental factors and host homeostasis.

Methods

Using metagenomic sequencing, we characterized the fecal archaeomes of 792 healthy adult subjects from 5 regions in China, spanning 6 ethnicities (Han, Zang, Miao, Bai, Dai, and Hani), consisting of both urban and rural residents for each ethnicity. In addition, we sampled 119 host variables (including lifestyle, diet, and blood parameters) and interrogated the influences of those fa

SUBMITTER: Bai X 

PROVIDER: S-EPMC9469561 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature