Investigation of CRS-associated cytokines in CAR-T therapy with meta-GNN and pathway crosstalk.

ABSTRACT:

Background

Chimeric antigen receptor T-cell (CAR-T) therapy is a new and efficient cellular immunotherapy. The therapy shows significant efficacy, but also has serious side effects, collectively known as cytokine release syndrome (CRS). At present, some CRS-related cytokines and their roles in CAR-T therapy have been confirmed by experimental studies. However, the mechanism of CRS remains to be fully understood.

Methods

Based on big data for human protein interactions and meta-learning graph neural network, we employed known CRS-related cytokines to comprehensively investigate the CRS associated cytokines in CAR-T therapy through protein interactions. Subsequently, the clinical data for 119 patients who received CAR-T therapy were examined to validate our prediction results.

SUBMITTER: Wei Z 

PROVIDER: S-EPMC9469618 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature