Effect of injection of different doses of isoproterenol on the hearts of mice.

ABSTRACT:

Background

Heart failure (HF) is one of the diseases that seriously threaten human health today and its mechanisms are very complex. Our study aims to confirm the optimal dose ISO-induced chronic heart failure mice model for better study of HF-related mechanisms and treatments in the future.

Methods

C57BL/6 mice were used to establish mice model of chronic heart failure. We injected isoproterenol subcutaneously in a dose gradient of 250 mg/kg, 200 mg/kg, 150 mg/kg, 100 mg/kg and 50 mg/kg. Echocardiography and ELISA were performed to figure out the occurrence of HF. We also supplemented the echocardiographic changes in mice over 30 days.

Results

Except group S and group E, echocardiographic abnormalities were found in other groups, suggesting a decrease in cardiac func

SUBMITTER: Pan Y 

PROVIDER: S-EPMC9469628 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature