A Case Report of Two Kala-azar Cases in China Diagnosed by Metagenomic Next-Generation Sequencing.

ABSTRACT:

Background

Leishmaniasis being a local disease, as kala-azar this particular form is a visceral form. It is transmitted by sandflies, and is a parasitic disease involving the reticuloendothelial system of mononuclear macrophages. Due to its poor prognosis and high fatality rate, the fatality rate of patients without effective treatment can exceed 95%. Thereby, early diagnosis and treatment can significantly improve its prognosis. The metagenomic next-generation sequencing (mNGS) has the advantage of being able to find pathogens that cannot be detected by traditional methods. More importantly, it can conduct nucleic acid detection of pathogens covering a wide range in a short time. For infectious diseases like kala-azar, which is clinically complicated and difficult, mNGS detection

SUBMITTER: Gao H 

PROVIDER: S-EPMC9469688 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature