Abetting host immune response by inhibiting rhipicephalus sanguineus Evasin-1: An in silico approach.

ABSTRACT: The brown dog tick (Rhipicephalus sanguineus) is the most prevalent tick in the world and a well-recognized vector of many pathogens affecting dogs and occasionally humans. Pathogens exploit tick salivary molecules for their survival and multiplication in the vector and transmission to and establishment in the hosts. Tick saliva contains various non-proteinaceous substances and secreted proteins that are differentially produced during feeding and comprise of inhibitors of blood congealing and platelet aggregation, vasodilatory and immunomodulatory substances, and compounds preventing itch and pain. One of these proteins is Evasin-1, which has a high binding affinity to certain types of chemokines. The binding of Evasin-1 to chemokines prevents the detection and immune response of the host

SUBMITTER: Castrosanto MA 

PROVIDER: S-EPMC9469951 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature