ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection.

ABSTRACT: Extracellular vesicles of endosomal origin, exosomes, mediate intercellular communication by transporting substrates with a variety of functions related to tissue homeostasis and disease. Their diagnostic and therapeutic potential has been recognized for diseases such as cancer in which signaling defects are prominent. However, it is unclear to what extent exosomes and their cargo inform the progression of infectious diseases. We recently defined a subset of exosomes termed defensosomes that are mobilized during bacterial infection in a manner dependent on autophagy proteins. Through incorporating protein receptors on their surface, defensosomes mediated host defense by binding and inhibiting pore-forming toxins secreted by bacterial pathogens. Given this capacity to serve as decoys that i

SUBMITTER: Ching KL 

PROVIDER: S-EPMC9469972 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature