Causal associations between gut microbiome and cardiovascular disease: A Mendelian randomization study.

ABSTRACT:

Background

Observational studies have shown gut microbiomes were associated with cardiovascular diseases (CVDs), but their roles remain controversial, and these associations have not yet been established causally.

Methods

Two-sample Mendelian randomization (MR) was used to investigate whether gut microbiome had a causal effect on the risk of CVDs. To obtain comprehensive results, we performed two sets of MR analyses, one with single nucleotide polymorphisms (SNPs) that smaller than the genome-wide statistical significance threshold (5 × 10^-8) as instrumental variables, and the other with SNPs that lower than the locus-wide significance level (1 × 10^-5). Summary-level statistics for CVDs, including coronary artery disease (CAD), myocardial infarction, he

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9470126 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature