Renal Histologic Findings in Necropsies of Type 2 Diabetes Mellitus Patients.

ABSTRACT:

Background

Very few studies have analyzed early histologic lesions of diabetic nephropathy (DN) in patients without signs of clinical involvement (microalbuminuria). In this study, we analyzed renal histologic lesions in necropsies of diabetic patients with or without previous signs of DN.

Methods

Histological material was analyzed from 21 autopsies of type 2 diabetes mellitus (T2DM) patients (9 with albuminuria and 12 without albuminuria) and 4 controls. Histologic lesions were evaluated according to the Tervaert classification.

Results

Kidneys of diabetic patients presented significantly higher scores in most histologic indices analyzed (glomerular basal membrane thickening, mild and severe mesangial expansion, nodular sclerosis, interstitial fibrosis, and tubular a

SUBMITTER: D'Marco L 

PROVIDER: S-EPMC9470369 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature