Longitudinal investigation of a xenograft tumor zebrafish model using polarization-sensitive optical coherence tomography.

ABSTRACT: Breast cancer is a leading cause of death in female patients worldwide. Further research is needed to get a deeper insight into the mechanisms involved in the development of this devastating disease and to find new therapy strategies. The zebrafish is an established animal model, especially in the field of oncology, which has shown to be a promising candidate for pre-clinical research and precision-based medicine. To investigate cancer growth in vivo in zebrafish, one approach is to explore xenograft tumor models. In this article, we present the investigation of a juvenile xenograft zebrafish model using a Jones matrix optical coherence tomography (JM-OCT) prototype. Immunosuppressed wild-type fish at 1-month post-fertilization were injected with human breast cancer cells and control anima

SUBMITTER: Lichtenegger A 

PROVIDER: S-EPMC9470556 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature