Energy balance-related factors and risk of colorectal cancer based on KRAS, PIK3CA, and BRAF mutations and MMR status.

ABSTRACT:

Introduction

KRAS mutations (KRAS_mut), PIK3CA_mut, BRAF_mut, and mismatch repair deficiency (dMMR) have been associated with the Warburg-effect. We previously observed differential associations between energy balance-related factors (BMI, clothing-size, physical activity) and colorectal cancer (CRC) subtypes based on the Warburg-effect. We now investigated whether associations between energy balance-related factors and risk of CRC differ between subgroups based on mutation and MMR status.

Methods

Information on molecular features was available for 2349 incident CRC cases within the Netherlands Cohort Study (NLCS), with complete covariate data available for 1934 cases and 3911 subcohort members. Multivariable-adjusted Cox-regression was used to

SUBMITTER: Jenniskens JCA 

PROVIDER: S-EPMC9470639 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature