Identification and validation of the role of c-Myc in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Many studies have shown that c-Myc plays a critical role in tumorigenesis. However, the molecular role of c-Myc in head and neck squamous cell carcinoma (HNSC) remains unclear.

Methods

Several biological databases, including UALCAN, TIMER2.0, TCGAportal, GEPIA, KM plotter, OncoLnc, LinkedOmics, GSCA, and TCIA, were used to analyze the molecular role of c-Myc in HNSC. The expression levels of c-Myc were validated by real-time PCR (RT-PCR) and Western blot in CAL-27 cells.

Results

The expression of c-Myc mRNA were significantly increased in HPV-negative HNSC tissues. The expression of c-Myc gene level was correlated with TP53 mutation status. HNSC also showed hypomethylated c-Myc compared with normal tissues. c-Myc was identified as an ominous prognostic fact

SUBMITTER: Zhao S 

PROVIDER: S-EPMC9470836 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature