Causal relationships between rheumatism and dyslipidemia: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Dyslipidemia is often observed in rheumatic diseases, such as ankylosing spondylitis (AS), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE), yet it remains to be detected whether rheumatic diseases have a causal effect on dyslipidemia.

Methods

Significant (P < 5 × 10^-8) and independent (r² < 0.1) single-nucleotide polymorphisms in genome-wide association studies were selected as instrumental variables to conduct Mendelian randomization (MR) analysis. Inverse variance weighted, weighted median, and MR-Egger regression were adopted for the causal inference. Subsequently, sensitivity analysis was conducted to assess the stability and reliability of MR.

Results

The MR results revealed positive causal relationships o

SUBMITTER: Zhang G 

PROVIDER: S-EPMC9470850 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature