Soluble guanylate cyclase activator BAY 54-6544 improves vasomotor function and survival in an accelerated ageing mouse model.

ABSTRACT: DNA damage is a causative factor in ageing of the vasculature and other organs. One of the most important vascular ageing features is reduced nitric oxide (NO)soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signaling. We hypothesized that the restoration of NO-sGC-cGMP signaling with an sGC activator (BAY 54-6544) may have beneficial effects on vascular ageing and premature death in DNA repair-defective mice undergoing accelerated ageing. Eight weeks of treatment with a non-pressor dosage of BAY 54-6544 restored the decreased in vivo microvascular cutaneous perfusion in progeroid Ercc1^∆/- mice to the level of wild-type mice. In addition, BAY 54-6544 increased survival of Ercc1^∆/- mice. In isolated Ercc1^∆/- aorta, the decreased endothel

SUBMITTER: Ataei Ataabadi E 

PROVIDER: S-EPMC9470884 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature