Nitric oxide-soluble guanylyl cyclase pathway as a contributor to age-related memory impairment in Drosophila.

ABSTRACT: Age-related changes in the transcriptome lead to memory impairment. Several genes have been identified to cause age-dependent memory impairment (AMI) by changes in their expression, but genetic screens to identify genes critical for AMI have not been performed. The fruit fly is a useful model for studying AMI due to its short lifespan and the availability of consistent techniques and environments to assess its memory ability. We generated a list of candidate genes that act as AMI regulators by performing a comprehensive analysis of RNAsequencing data from young and aged fly heads and genome-wide RNAi screening data to identify memory-regulating genes. A candidate screen using temporal and panneuronal RNAi expression was performed to identify genes critical for AMI. We identified the guanyl

SUBMITTER: Tonoki A 

PROVIDER: S-EPMC9470885 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature