Brief Report: Undercarboxylated Osteocalcin Is Associated With Cognition in Women With and Without HIV.

ABSTRACT:

Introduction

Bone loss and cognitive impairment are common in women living with HIV (WLWH) and are exacerbated by menopause. Bone-derived undercarboxylated osteocalcin (ucOCN) and sclerostin appear to influence cognition. The current study investigated whether the circulating levels of these 2 proteins are associated with cognition in midlife WLWH and demographically similar HIV seronegative women.

Methods

Plasma samples from women enrolled in a musculoskeletal substudy within the Women's Interagency HIV Study were used to measure ucOCN and sclerostin. A neuropsychological (NP) test battery assessing executive function, processing speed, attention/working memory, learning, memory, verbal fluency, and motor function was administered within 6 months of musculoskeletal enrollme

SUBMITTER: Ross RD 

PROVIDER: S-EPMC9470989 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature