PIEZO1 mechanoreceptor activation reduces adipogenesis in perivascular adipose tissue preadipocytes.

ABSTRACT: During hypertension, vascular remodeling allows the blood vessel to withstand mechanical forces induced by high blood pressure (BP). This process is well characterized in the media and intima layers of the vessel but not in the perivascular adipose tissue (PVAT). In PVAT, there is evidence for fibrosis development during hypertension; however, PVAT remodeling is poorly understood. In non-PVAT depots, mechanical forces can affect adipogenesis and lipogenic stages in preadipocytes. In tissues exposed to high magnitudes of pressure like bone, the activation of the mechanosensor PIEZO1 induces differentiation of progenitor cells towards osteogenic lineages. PVAT's anatomical location continuously exposes it to forces generated by blood flow that could affect adipogenesis in normotensive and hy

SUBMITTER: Rendon CJ 

PROVIDER: S-EPMC9471253 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature