Effects of human induced pluripotent stem cell-derived intestinal organoids on colitis-model mice.

ABSTRACT:

Introduction

Ulcerative colitis (UC) is an inflammatory bowel disease characterized by repeated remissions and relapses. Immunosuppressive drugs have facilitated the induction and maintenance of remission in many patients with UC. However, immunosuppressive drugs cannot directly repair impaired intestinal mucosa and are insufficient for preventing relapse. Therefore, new treatment approaches to repair the damaged epithelium in UC have been attempted through the transplantation of intestinal organoids, which can be differentiated into mucosa by embedding in Matrigel, generated from patient-derived intestinal stem cells. The method, however, poses the challenge of yielding sufficient cells for UC therapy, and patient-derived cells might already have acquired pathological changes. In

SUBMITTER: Nakanishi A 

PROVIDER: S-EPMC9471335 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature