The nematode serotonin-gated chloride channel MOD-1: A novel target for anthelmintic therapy.

ABSTRACT: Anthelmintics are used to treat human and veterinary parasitic diseases and to reduce crop and livestock production loss associated with parasitosis. The free-living nematode Caenorhabditis elegans, a model system for anthelmintic drug discovery, has a serotonin (5-HT)-gated chloride channel, MOD-1, which belongs to the Cys-loop receptor family and modulates locomotory and behavioral functions. Since MOD-1 is unique to nematodes, it is emerging as an attractive anthelmintic drug target, but details of MOD-1 function are unclear. Here, we revealed novel aspects of MOD-1 function from the molecular level to the organism level and identified compounds targeting this receptor, which may provide new directions for anthelmintic drug discovery. We used whole-cell current recordings from heterolog

SUBMITTER: Rodriguez Araujo N 

PROVIDER: S-EPMC9471462 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature